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KMID : 0377220010260020043
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Medical Journal of Chosun Univercity
2001 Volume.26 No. 2 p.43 ~ p.49
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Significance of expression of p53, cyclin D1 and cathepsin D in breast carcinoma
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Moon Kyung-Rye
Kim Hwan-Jong
Lee Mi-Ja
Kee Keun-Hong
Suh Chae-Hong
Yang Jeong-Won
Cho Hyun-Jin
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Abstract
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Background and Objectives: Breast carcinoma is a heterogenous disease. The prognosis of this carcinoma correlates with various prognostic factors. The aim of this study was to assess the prognostic significance of expression of p53, cyclin Dl and cathepsin D protiens in association with various prognostic factors in invasive breast carcinoma.
Materials and Methods: The relationship is presented between expression of p53, cyclin D1 and cathepsin D by immunohistochemistry and various established prognostic factors such as tumor size, histologic grade, lymph node status and extensive intraductal component in 55 cases of invasive breast carcinoma.
Results: No significant correlations were observed between expression of p53, cyclin Dl and cathepsin D and tumor size. The expression of p53 correlated with high histologic grade. The expression of p53 and cyclin Dl correlated with lymph node metastasis.
Conclusion: These results indicate that expression of p53 and cyclin Dl in invasive ductal carcinoma may be an important prognostic factor, closely related to the high histologic grade and lymph node metastasis.
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KEYWORD
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Invasive breast carcinoma, p53, Cyclin D1, Cathepsin D
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